Abstract: 7-ACA dust has a risk of explosion in the production process. In order to study the explosion mechanism of 7-ACA dust, experiments were carried out by using TGA method. Heating rates of 10, 20 and 30 ℃/min were used in the experiments. Experiments show that the minimum fire temperature of 7-ACA dust is 220 ℃ at the rate of temperature increase being 10 ℃/min, that the higher the rate of temperature increase is, the higher both the minimum fire temperature and the temperature corresponding to the maximum weight loss rate will be, that for the cracking stage, the activation energy is 7.347 kJ/mol, the pre-exponential factor is 1.4×10⁷ and the reaction is 1.5 a order reaction, that for the combustion stage, the activation energy is 146.99 kJ/mol, the pre-exponential factor is 9.18×10¹¹ and the reaction is a 2 order reaction, and that the values of thermal dynamics parameters are not high for the whole process and 7-ACA dust can be ignited with a small amount of energy and poses a risk of explosion.

Key words: 7-amino-cephalosporanic-acid(7-ACA), explosion mechanism, thermal dynamics, thermogravimetric analysis(TGA), pyrolysiss