Abstract: Based on the frequently-occurring explosion accidents in pharmaceutical industry in recent years, the categories of explosion accidents were analyzed. With the dust explosion of a pharmaceutical enterprise as the object of study, an explosive parameter test was conducted on the powder of potassium clavulanate in a 20-L spherical dust explosion test equipment, which shows that the lower explosive limit of potassium clavulanate is about 40g/m~3. And then Differential Scanning Calorimeter (DSC) was used to study the rules of heat releasing of the explosion and Gas Chromatograph (GC) was used to measure whether there was any combustible gas existing in the compound, the measurement shows that there exists acetone gas with a lower concentration of 9.3×10~(-5). Based on the above study achievements, countermeasures were proposed and common problems were analyzed from the technical and management point of view. Meanwhile, the human-machine interface of the meal mixer was designed, the safety checklist was compiled, and such common problems were summed up. This study can provide an important reference for the prevention and control of dust explosion accidents in pharmaceutical industry.