Effect of liver enzymes on association between metabolically healthy obesity and hyperuricemia in steelworkers

doi:10.16265/j.cnki.issn1003-3033.2024.02.1184

Abstract

Abstract:

The association between MHO and HUA and whether liver enzyme abnormalities could modify this association were studied. The cross-sectional study was conducted using 6,868 steelworkers in Hebei Iron and Steel Company who participated in occupational medical examinations as the study population. The data were analyzed using logistic regression models and interaction effect model. The results show that, in a multiple adjusted logistic model, the risk of HUA is increased 2.13-fold (odds ratio (OR)=2.13, 95% confidence interval (CI): 1.08-4.21) for metabolically healthy generalized obesity (MHGO). The risk of HUA is increased 2.25-fold (OR=2.25,95%CI: 1.14-4.45) for metabolically healthy abdominal obesity (MHAO). In stratified analysis, in the group with elevated liver enzymes, the prevalence of HUA in steelworkers with MHO(MHGO and MHAO) is significantly higher than that in the group with normal liver enzymes, and the interaction between obesity phenotypes and liver enzyme levels has a statistically significant effect on HUA (P<0.05). MHO is associated with a high prevalence of HUA. Liver enzyme levels may alter the relationship between MHO and HUA.

Key words: liver enzymes, steelworkers, metabolically healthy obesity (MHO), hyperuricemia (HUA), generalized obesity(GO), abdominal obesity(AO)

CLC Number:

X910安全人体学

YU Miao, ZHANG Shengkui, WANG Lihua, YUAN Juxiang. Effect of liver enzymes on association between metabolically healthy obesity and hyperuricemia in steelworkers[J]. China Safety Science Journal, 2024, 34(2): 231-238.

Figures/Tables 6

Tab.1

Characteristic distribution of HUA disease groups of steelworkers

变量		总计	非HUA	HUA	P
变量		n=6 868	n=4 595	n=2 273	P
年龄/岁,n/%	22~29	334 (4.9)	187 (4.1)	147 (6.5)	< 0.001
	30~39	1 582 (23.0)	910 (19.8)	672 (29.6)
	40~49	2 757 (40.1)	1 884 (41.0)	873 (38.4)
	50~60	2 195 (32.0)	1 614 (35.1)	581 (25.6)
教育程度,n/%	高中及以下	5 305 (77.2)	3 614 (79.2)	1 664 (73.2)	< 0.001
教育程度,n/%	大专及以上	1 563 (22.8)	954 (20.8)	609 (26.8)	< 0.001
吸烟,n/%	从不	2 842 (41.4)	1 975 (43.0)	867 (38.1)	< 0.001
	曾经	460 (6.7)	305 (6.6)	155 (6.8)
	现在	3 566 (51.9)	2 315 (50.4)	1 251 (55.1)
饮酒,n/%	从不	3 954 (57.5)	2 709 (59.0)	1 245 (54.8)	0.002
	曾经	245 (3.6)	167 (3.6)	78 (3.4)
	现在	2 669 (38.9)	1 719 (37.4)	950 (41.8)
体力活动,n/%	低	1 247 (18.2)	785 (17.1)	462 (20.3)	< 0.001
	中	3 447 (50.2)	2 371 (51.6)	1 076 (47.3)
	高	2 174 (31.6)	1 439 (31.3)	735 (32.3)
GO,n/%	否	3 138 (45.7)	2 395 (52.1)	743 (32.7)	< 0.001
GO,n/%	是	3 730 (54.3)	2 200 (47.9)	1 530 (67.3)	< 0.001
AO,n/%	否	2 302 (33.5)	1 746 (38.0)	556 (24.5)	< 0.001
AO,n/%	是	4 566 (66.5)	2 849 (62.0)	1 717 (75.5)	< 0.001
倒班作业,n/%	否	1 316 (19.2)	922 (20.1)	394 (17.3)	0.007
倒班作业,n/%	是	5 552 (80.8)	3 673 (79.9)	1 879 (82.7)	0.007
粉尘作业,n/%	否	2 595 (37.8)	1 783 (38.8)	812 (35.7)	0.013
粉尘作业,n/%	是	4 273 (62.2)	2 812 (61.2)	1 461 (64.3)	0.013
噪声作业,n/%	否	3 367 (49.0)	2 273 (49.5)	1 094 (48.1)	0.297
噪声作业,n/%	是	3 501 (51.0)	2 322 (50.5)	1 179 (51.9)	0.297
高温作业,n/%	否	3 481 (50.7)	2 412 (52.5)	1 069 (47.0)	< 0.001
高温作业,n/%	是	3 387 (49.3)	2 183 (47.5)	1 204 (53.0)	< 0.001
CO作业,n/%	否	3 952 (57.5)	2 660 (57.9)	1 292 (56.8)	0.408
CO作业,n/%	是	2 916 (42.5)	1 935 (42.1)	981 (43.2)	0.408
年龄/岁, ( $χ -$ ±S)		44.6±8.1	45.5±7.8	42.9±8.3	< 0.001
DASH评分,( $χ -$ ±S)		25.4±5.8	25.5±5.8	25.2±5.6	0.039
SBP/mmHg,( $χ -$ ±S)		129.0±15.9	128.0±16.0	130.8±15.6	< 0.001
DBP/mmHg,( $χ -$ ±S)		82.5±10.4	82.0±10.2	83.7±10.5	< 0.001
TC/(mmol·L^-1),( $χ -$ ±S)		5.1±1.0	5.1±0.9	5.2±1.0	< 0.001
TG/(mmol·L^-1),M (IQR)		1.3 (0.9-2.0)	1.2 (0.8-1.7)	1.6 (1.1-2.4)	< 0.001
HDL-C/(mmol·L^-1),( $χ -$ ±S)		1.3±0.3	1.3±0.3	1.2±0.3	< 0.001
LDL-C/(mmol·L^-1),( $χ -$ ±S)		3.2±0.9	3.2±0.8	3.3±0.9	< 0.001
FBG/(mmol·L^-1),( $χ -$ ±S)		6.1±1.3	6.1±1.5	6.0±1.0	< 0.001
ALT/(U·L^-1),M (IQR)		23 (17-31)	21 (16-28)	26 (20-37)	< 0.001
AST/(U·L^-1),M (IQR)		20 (17-23)	19 (17-22)	21 (18-25)	< 0.001
GGT/(U·L^-1),M (IQR)		26 (19-41)	24 (17-36)	32 (23-51)	< 0.001

Tab.1

Tab.2

Tab.3

Fig.1

Fig.2

Tab.4

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变量		模型1	模型2	模型3	模型4
GO	否	1.00	1.00	1.00	1.00
GO	是	2.24(2.02~2.49)	2.14 (1.92~2.38)	2.34 (1.90~2.89)	2.15 (1.74 ~2.66)
AO	否	1.00	1.00	1.00	1.00
AO	是	1.89 (1.69 - 2.12)	1.88 (1.68~2.11)	2.35 (1.86~2.97)	2.15 (1.69~2.72)
代谢异常组分	BP	1.47(1.33~1.63)	1.58 (1.42~1.76)	1.57 (1.27~1.94)	1.49 (1.20~1.84)
	FBG	1.05 (0.95~1.17)	1.12 (1.00~1.25)	1.18 (0.94~1.48)	1.14 (0.91~1.43)
	TG	2.59 (2.33~2.88)	2.51 (2.26~2.80)	2.62 (2.13 ~3.22)	2.36 (1.91 ~2.92)
	HDL-C	1.66 (1.47~1.89)	1.69 (1.48~1.92)	1.36 (1.05~1.75)	1.31 (1.01~1.70)
代谢异常数量	0	1.00	1.00	1.00	1.00
	1	1.13 (0.94~1.37)	0.93 (0.71~1.20)	1.08 (0.73~1.59)	1.03 (0.70~1.52)
	2	1.62 (1.35~1.95)	1.25 (0.97~1.60)	1.64 (1.12~2.40)	1.50 (1.03~2.21)
	3	2.88 (2.37~3.50)	1.41 (1.08~1.85)	2.96 (1.98~4.43)	2.53 (1.68~3.81)
	4	3.14 (2.43~4.07)	1.68 (1.19~2.37)	3.11 (1.87~5.19)	2.70 (1.61~4.52)

肥胖表型		患病人数/%	OR (95% CI)值
肥胖表型		患病人数/%	模型1	模型2	模型3	模型4
BMI 分类	MHNGO	105 (18.1)	1.00	1.00	1.00	1.00
	MUNGO	638 (24.9)	1.50(1.20~1.90)	1.67 (1.32~2.11)	1.40 (0.87~2.27)	1.28 (0.79~2.08)
	MHGO	88 (35.3)	2.47 (1.77~3.46)	2.36 (1.68~3.32)	2.41 (1.23~4.73)	2.13 (1.08~4.21)
	MUGO	1442 (41.4)	3.20 (2.56~3.99)	3.37(2.69~4.24)	3.18 (1.99 ~5.06)	2.70 (1.69~4.32)
WC 分类	MHNAO	91/456 (20.0)	1.00	1.00	1.00	1.00
	MUNAO	465/1 846 (26.9)	1.35 (1.05~1.74)	1.45 (1.12~1.87)	1.50 (0.85~2.63)	1.38 (0.79~2.42)
	MHAO	102/373 (27.4)	1.51 (1.09~3.19)	1.44(1.03~2.00)	2.46 (1.25~4.85)	2.25 (1.14~4.45)
	MUAO	1 615/4 193 (38.5)	2.51 (1.98~3.19)	2.70(2.11~3.45)	3.38 (1.98~5.78)	2.87 (1.68~4.93)

肥胖表型		分组1^a		P	分组2^b		P
肥胖表型		肝酶正常	肝酶异常	P	肝酶正常	肝酶异常	P
BMI 分类	MHNGO	1.00	1.00	<0.001	1.00	1.00	<0.001
	MUNGO	1.04 (0.49~2.20)	1.30 (0.69~2.46)		0.96 (0.58~1.59)	1.06 (0.65~1.74)
	MHGO	1.80 (0.79~4.14)	3.52 (1.05~11.81)		1.91 (0.87~4.19)	2.19 (1.51~3.19)
	MUGO	2.41 (1.15~5.04)	2.50 (1.35~4.63)		2.10 (1.29~3.43)	2.92 (2.28~3.74)
WC 分类	MHNAO	1.00	1.00	<0.001	1.00	1.00	<0.001
	MUNAO	0.65 (0.28~1.51)	1.78 (0.81~3.92)		1.03 (0.57~1.85)	1.09 (0.54~2.17)
	MHAO	1.57 (0.51~4.85)	2.50 (1.02~6.17)		2.02 (0.96~4.27)	1.33 (0.56~3.17)
	MUAO	2.01 (0.95~4.27)	3.14 (1.47~6.72)		2.19 (1.26~3.82)	1.93 (1.13~3.37)