Abstract: The concepts of information system security and architecture are defined at first. Then related research contents in this field are introduced, and several popular architectures are analyzed. The characteristics of important information system and the advantages and disadvantages of terminal security system architecture based on trusted computation are analyzed emphatically. On this basis, a scheme combining trusted computation and security mechanism is proposed, and a design thread for security system architecture of information security assessment system is presented, which provides innovative reference for the security building of important information system under network environment.