Abstract: Based on the simulated laboratory experiment of pressure balance for fire extinguishing, the pressure regulating technique in the burning section of Meiyukou coal mine is summarized. Three pressure regulating measures, namely the application of pressure regulating air chamber to balance the air pressure of burning section, increasing the air pressure of the working face, and filling the surface crannies, are very effective in preventing and extinguishing the fire. Among these three measures, notwithstanding the pressure regulation for the working face or the air chamber pressure regulation failed, the measure of filling the surface crannies will play a very important role.