Abstract: In order to improve the efficiency of safety management and effectively solve the problem in locale decision-making as well as standardize law-enforcing procedures,a mobile office information system for safety management is designed with the VB.NET as the developing language,WINCE.NET as the operating environment and SQL as the background supporting database.This system combines the work features of safety management and the information demands for locale safety management,and brings the advantages of portable features and secondary development features of PDA into full play.In this system,nine function modules such as safety management,supervision of law enforcement,ete.,are designed,which can complete data communication with two editions of back-end supporting platform,such as Enterprise Edition and Management Edition.The application of this system shows that the mobile office information system for safety management is an important technical means to realize the informatization of safety management and enhance the level of safety management.