In order to promote the discipline development and specialty construction of national safety science and engineering, based on the national " double first-class " discipline and curriculum " double ten thousand " plan and the goal and connotation of new engineering construction, this paper, according to the characteristics of safety science and engineering discipline, used system theory and collaborative development method to clarify the internal relationship among discipline, specialty and curriculum construction and analyzed the internal among them. Starting from the connotation development of higher education and the construction policy of education power, this paper put forward the representation mode of safety discipline in the collaborative construction of discipline, specialty, and curriculum. The innovation of safety innovative talents training in three aspects of education, the concept, training mode, and guarantee mechanism, were introduced. According to the requirements of new engineering construction, the coordinated development path of disciplines, specialties, and curriculums was constructed, and different solutions were proposed from five aspects: curriculum construction, innovative talents training, teacher connotation construction, and ideological and political guidance organization platform construction. Through multiple measures, the training system of safety innovative talents and the concept of innovative talents training reformed to promote the organic combination and comprehensive, high-speed, and coordinated development of the three, providing a reference for the collaborative construction of disciplines, specialties, curriculums and personnel training of similar disciplines.